The A4 study: Now is the time to join the fight to prevent Alzheimer's disease.

Feasibility Study Conducted for A4 Trial

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
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Depression screening in cognitively normal older adults: Measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex

Thompson, L. I., & Jones, R. N. (2020). Depression screening in cognitively normal older adults: Measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex. Alzheimer’s & dementia (Amsterdam, Netherlands), 12(1), e12107. ht
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Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants

Harkins, K., Sankar, P., Sperling, R., Grill, J. D., Green, R. C., Johnson, K. A., … & Karlawish, J. (2015). Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants. Alzheimer’s research & therapy, 7(1), 1-9.
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KL* VS Heterozygosity Reduces Brain Amyloid in Asymptomatic at Risk APOE* 4 Carriers.

Belloy, M. E., Eger, S. J., Le Guen, Y., Napolioni, V., Deters, K. D., Yang, H. S., … & Alzheimer’s Disease Neuroimaging Initiative. (2021). KL* VS Heterozygosity Reduces Brain Amyloid in Asymptomatic at Risk APOE* 4 Carriers. Neurobiology of Aging.
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Genetic variants and functional pathways associated with resilience to Alzheimer’s disease

Dumitrescu, L., Mahoney, E. R., Mukherjee, S., Lee, M. L., Bush, W. S., Engelman, C. D., … & Hohman, T. J. (2020). Genetic variants and functional pathways associated with resilience to Alzheimer’s disease. Brain, 143(8), 2561-2575.
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Short-term psychological outcomes of disclosing amyloid imaging results to research participants who do not have cognitive impairment

Grill, J. D., Raman, R., Ernstrom, K., Sultzer, D. L., Burns, J. M., Donohue, M. C., … & A4 Study Team. (2020). Short-term psychological outcomes of disclosing amyloid imaging results to research participants who do not have cognitive impairment. JAMA neurology, 77(12), 1504-1513.
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Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals

Sperling, R. A., Donohue, M. C., Raman, R., Sun, C. K., Yaari, R., Holdridge, K., … & Aisen, P. S. (2020). Association of factors with elevated amyloid burden in clinically normal older individuals. JAMA neurology, 77(6), 735-745.
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The computerized cognitive composite (c3) in a4, an alzheimer’s disease secondary prevention trial.

Papp, K. V., Rentz, D. M., Maruff, P., Sun, C. K., Raman, R., Donohue, M. C., … & Sperling, R. A. (2020). The computerized cognitive composite (c3) in a4, an alzheimer’s disease secondary prevention trial. The journal of prevention of Alzheimer’s disease, 1-9.
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Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study.

Marshall, G. A., Sikkes, S. A., Amariglio, R. E., Gatchel, J. R., Rentz, D. M., Johnson, K. A., … & Full listing of A4 Study team and site personnel available at A4STUDY. org. (2020). Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adult
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The A4 study: β‐amyloid and cognition in 4432 cognitively unimpaired adults

Insel, P. S., Donohue, M. C., Sperling, R., Hansson, O., & Mattsson‐Carlgren, N. (2020). The A4 study: β‐amyloid and cognition in 4432 cognitively unimpaired adults. Annals of clinical and translational neurology, 7(5), 776-785.
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