Gene- and age-informed screening for preclinical Alzheimer’s disease trials
Spencer BE, Digma LA, Jennings RG, Brewer JB. Alzheimers Dement. 2021;17(3):457-465. READ MORE
KL*VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE* 4 carriers
Belloy, M. E., Eger, S. J., Le Guen, Y., Napolioni, V., Deters, K. D., Yang, H. S., … & Alzheimer’s Disease Neuroimaging Initiative. Neurobiol Aging. 2021 May; 101: 123–129. READ MORE
Harmonizing the preclinical Alzheimer cognitive composite for multi‐cohort studies: Developments in clinical trials and cognitive assessment
Hampton OL, Mukherjee S, Properzi MJ, et al. Alzheimer’s & dementia. 2020;16. READ MORE
Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study
Marshall, G. A., Sikkes, S. A., Amariglio, R. E., Gatchel, J. R., Rentz, D. M., Johnson, K. A., … & Full listing of A4 Study team and site personnel available at A4STUDY. org. Alzheimers Dement (Amst). 2020; 12(1): e12118. READ MORE
Depression screening in cognitively normal older adults: Measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex
Thompson, L. I., & Jones, R. N. (2020). Alzheimers Dement (Amst). 2020; 12(1): e12107. READ MORE
Genetic variants and functional pathways associated with resilience to Alzheimer's disease
Dumitrescu, L., Mahoney, E. R., Mukherjee, S., Lee, M. L., Bush, W. S., Engelman, C. D., … & Hohman, T. J. Brain. 2020 Aug; 143(8): 2561–2575. READ MORE
Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment
Grill, J. D., Raman, R., Ernstrom, K., Sultzer, D. L., Burns, J. M., Donohue, M. C., … & A4 Study Team. JAMA Neurol. 2020 Dec; 77(12): 1–10. READ MORE
The Computerized Cognitive Composite (C3) in A4, an Alzheimer’s Disease Secondary Prevention Trial
Papp, K. V., Rentz, D. M., Maruff, P., Sun, C. K., Raman, R., Donohue, M. C., … & Sperling, R. A. J Prev Alzheimers Dis. 2021; 8(1): 59–67. READ MORE
The A4 study: beta-amyloid and cognition in 4432 cognitively unimpaired adults
Insel, P. S., Donohue, M. C., Sperling, R., Hansson, O., & Mattsson‐Carlgren, N. (2020). Ann Clin Transl Neurol. 2020 May; 7(5): 776–785. READ MORE
Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals
Sperling, R. A., Donohue, M. C., Raman, R., Sun, C. K., Yaari, R., Holdridge, K., … & Aisen, P. S. JAMA Neurol. 2020 Jun; 77(6): 1–11. READ MORE
