Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults: A Machine Learning Approach Using A4 Data
Petersen KK, Lipton RB, Grober E, Davatzikos C, Sperling RA, Ezzati A. Neurology. 2022;98(24):e2425-e2435. READ MORE
Journal Articles
Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease
Young CB, Winer JR, Younes K, et al. JAMA neurology; JAMA Neurol. 2022;79(6):592-603. READ MORE
Associations of Stages of Objective Memory Impairment With Amyloid PET and Structural MRI:The A4 Study
Grober E, Lipton RB, Sperling RA, et al. Neurology. 2022;98(13):e1327-e1336. READ MORE
Analyzing the future time perspective scale in the baseline period in the Anti-Amyloid treatment in Asymptomatic Alzheimer’s Disease (A4) Study
Stites SD, Dedhia M, Grill JD, Karlawish J. Alzheimer’s & dementia. 2021;17:n/a. READ MORE
Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: Screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies
Spira AP, Zipunnikov V, Raman R, et al. Sleep Adv. 2021; 2(1): zpab015. READ MORE
Association of short and long sleep duration with amyloid-beta burden and cognition in aging
Joseph R Winer 1 , Kacie D Deters 1 , Gabriel Kennedy 1 , Meghan Jin 1 , Andrea Goldstein-Piekarski 2 3 , Kathleen L Poston 1 , Elizabeth C Mormino 1. JAMA Neurol. 2021 Oct; 78(10): 1–10. READ MORE
Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) trial
Ngolab J, Donohue M, Belsha A, et al. Alzheimer’s & dementia: diagnosis, assessment & disease monitoring; Alzheimers Dement (Amst). 2021;13(1):e12199-n/a. READ MORE
Association of sleep and beta-amyloid pathology among older cognitively unimpaired adults
Insel PS, Mohlenhoff BS, Neylan TC, Krystal AD, Mackin RS. JAMA network open; JAMA Netw Open. 2021;4(7):e2117573. READ MORE
Predicting amyloid risk by machine learning algorithms based on the A4 screen data: Application to the Japanese Trial-Ready Cohort study
Sato K, Ihara R, Suzuki K, et al. Alzheimer’s & dementia : translational research & clinical interventions; Alzheimers Dement (N Y). 2021;7(1):e12135-n/a. READ MORE
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A4 Study Organizers
The A4 Study is a landmark public-private partnership, funded by the National Institute on Aging/NIH, Eli Lilly and Company, and several philanthropic organizations. The A4 trial is coordinated by the University of Southern California’s Alzheimer’s Therapeutic Research Institute, with study sites in multiple locations.
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